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The twenty-first century has witnessed remarkable advances in medical science, resulting in improved diagnosis, treatment, and management of numerous diseases. Despite these achievements, chronic diseases continue to pose one of the greatest challenges to global health. Conditions such as Diabetes Mellitus and Hypertension have become increasingly prevalent, affecting millions of individuals across diverse populations. While their physical manifestations are well documented, their psychological consequences often remain underappreciated in both clinical practice and public health discourse. This book has been written to address that critical gap by presenting a comprehensive psychological perspective on chronic diseases. The foundation of this book is an empirical research study entitled "Psychological Impact of Chronic Diseases on Mental Depression, Alienation, and Neuroticism of Patients." However, this volume is not merely a reproduction of a research dissertation. Rather, it is a carefully revised, expanded, and reader-oriented academic book that translates scientific findings into a coherent and accessible resource for students, researchers, healthcare professionals, and mental health practitioners. The central objective is to demonstrate that chronic diseases are not solely biological conditions but complex human experiences that influence psychological adjustment, emotional well-being, social functioning, and overall quality of life.