A Textbook of Fundamentals of Medicinal Chemistry

ISBN-978-93-6175-687-0

The “A Textbook of Fundamentals of Medicinal Chemistry”, as an interdisciplinary
science, merges principles of chemistry, biology, and pharmacology to discover, design, and
develops therapeutic agents. The purpose of this text is to provide a comprehensive overview
of the fundamentals of medicinal chemistry, emphasizing the relationship between chemical
properties and biological actions of drugs. From historical developments to modern advances,
such as QSAR and molecular modeling, each chapter aims to bridge traditional concepts with
innovative techniques in drug design and development.
The initial chapters cover general principles, including drug metabolism and physico-chemical
properties affecting biological function. Subsequent sections delve into specific drug classes—
adrenergic and cholinergic agents, CNS-active drugs, cardiovascular drugs, and
antihistamines—focusing on their mechanisms, therapeutic actions, and structural attributes.
Later chapters introduce antibiotics, antineoplastic agents, and anti-infective drugs, exploring
their pharmacodynamics and the development of drug resistance.
In addition, the book discusses agents acting on the endocrine system, anti-diabetics, local
anesthetics, and agents for treating conditions like protozoal infections and helminthiasis. The
text also delves into sulphonamides and drug design methodologies, such as pharmacophore
modeling and combinatorial chemistry, presenting the tools and strategies essential in modern
medicinal chemistry research.
This text serves as a resource for B Pharmacy students, researchers, and professionals seeking
to deepen their understanding of Fundamentals of medicinal chemistry and its applications in
developing effective therapeutic agents.
-Dr. Somashekhar M. Metri
-Mr. Shivanand Kolageri
-Dr. Vishal Bharat Babar,
-Dr. Pratik Praksh Maske
-Dr. A.R. Mahesh
-Dr. Pramila.T,
-Ms. Maharani H. Bhandarakavathe