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Welcome to the second volume of “Medicinal Chemistry Theory,” a comprehensive
exploration of the principles and practices that underpin the fascinating field of medicinal
chemistry. This volume, Medicinal Chemistry Theory-II, builds upon the foundation laid in
the first volume and delves deeper into the intricate world of drug discovery and design.
When chemistry, biology, and pharmacology come together, you get medicinal chemistry, a
vibrant and interdisciplinary field. Its main purpose is to create new medicines that can be used
to treat illnesses and boost people’s health. In this volume, we continue our investigation of the
molecular interactions that determine the pharmacological activity of substances and its
application in drug creation.
The discovery of potentially life-saving medications has been greatly aided by the insights
gained from medicinal chemistry studies. The work of medicinal chemists is essential in the
development of new therapeutics, from small molecule inhibitors to biologics and gene
therapies.Structure of the Book: Medicinal Chemistry Theory-II comprises several chapters, each
dedicated to a specific aspect of the drug discovery process. We begin with a recap of key
concepts from the first volume, providing a seamless transition for readers who may be new to
this book series. However, each chapter can also be read independently for those seeking indepth knowledge on particular topics.
The chapters in this volume cover a wide range of subjects, including:
1. Drug Metabolism and Pharmacokinetics: Understanding how drugs are metabolized
and how their concentration in the body changes over time.
2. Structure-Activity Relationship (SAR) Studies: Exploring the relationship between
the chemical structure of compounds and their biological activity.
3. Drug Design Strategies: Examining various approaches employed by medicinal
chemists to design novel drugs with enhanced potency and selectivity.
4. Enzyme Inhibitors: Investigating the design and mechanisms of enzyme inhibitors as
potential therapeutics.

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