PHARMACEUTICAL INORGANIC AND ANALYTICAL CHEMISTRY

A Text Book of Physical Pharmaceutics is a comprehensive textbook that introduces students to the fundamental principles of physics and physical chemistry applied to pharmaceutical sciences. It explains how the physicochemical properties of drugs and excipients influence formulation, stability, manufacturing, quality, and therapeutic performance. The book covers five major areas of physical pharmaceutics. The first chapter focuses on solubility, distribution phenomena, and buffer systems, explaining their importance in drug formulation and dosage-form development. The second chapter discusses interfacial phenomena, including surface and interfacial tension, surfactants, HLB, adsorption, wetting, electrical double layers, and zeta potential. The third chapter covers colloidal and coarse dispersions, their classification, properties, stability, and pharmaceutical applications. The fourth chapter deals with rheology, emphasizing flow and deformation behavior relevant to pharmaceutical formulations. The final chapter presents micromeritics, covering particle size, particle-size distribution, particle shape, surface area, powder-flow properties, evaluation methods, and applications in dosage-form manufacturing and advanced drug delivery. Overall, the book provides a clear, systematic, and application-oriented foundation for understanding physical pharmaceutics and its role in modern pharmaceutical formulation and technology.